Side effects of painkillers
U.S. company Merck Vioxx costs nearly a billion
Authorities make the painkiller Vioxx for tens of thousands of heart attacks is responsible. The U.S. pharmaceutical giant Merck has taken it off the market years ago. The debate about the side effects continue to this day. Now, the manufacturer must pay nearly a billion dollars because he had sold the drug without approval.
The U.S. again Pharmarkonzern Merck paid almost a billion dollars to settle the dispute over the painkiller Vioxx. Merck has admitted to having sold Vioxx as a treatment for rheumatoid arthritis, before the U.S. Food and Drug Administration has granted to the appropriate approval.
Because of the side effects of the painkiller Vioxx, the U.S. manufacturer Merck has already paid nearly five billion dollars. Now added another 950 million.
A total of $ 950 million, the Group must now expend in order - roughly a third of which is attributable to a penalty, the remaining million of receivables from civil lawsuits. The pharmaceutical companies had already formed in the past year now agreed provisions in the amount of payment.
Merck & Co., not to be confused with the German drugmaker Merck KGaA, Vioxx had not only sold from 1999 as a painkiller, but also as a drug against rheumatoid arthritis. Only in 2004 the anti-inflammatory drug was withdrawn from the market after being linked with numerous heart attacks and strokes. In its advertising, however, have made Merck lied about the possible risks for the heart to the sales figures continue to push upward, said the Justice Department.
According to the U.S. Pharmacopoeia and Food Inspection FDA may for a period of five years 88000-139000 heart attacks are attributed to the ingestion of Vioxx. Up to 40 percent of which were fatal.
Already in 2007, Merck had reached an agreement out of court with the great majority of thousands of plaintiffs, which provided for the payment of 4.85 billion dollars. Then as now, the company said, it was not an admission of guilt connected.
Wednesday 7 December 2011
Diarrhea can be drug side effect
Diarrhea can be a side effect of various drugs. Quite often it occurs after taking antibiotics. He usually remains harmless. More than two days, he should pause, however. Then a doctor visit is appropriate.
Diarrhea can also be caused by medication.
Berlin - Diarrhea can be a side effect of various drugs. Quite often it occurs after taking antibiotics. He usually remains harmless. More than two days, he should pause, however. Then a doctor visit is appropriate.
"Diarrhea as side effects of antibiotics are usually harmless and disappear within a few days by themselves they hold more than two days, a doctor should be consulted," says Thorsten Gottwald of the Federal Chamber of Pharmacists, Berlin. Antibiotics kill bacteria and thus also some of the desirable intestinal bacteria. One possible result is diarrhea because nutrients are not completely degraded by the intestinal bacteria. Anyone who has diarrhea should drink a lot and replace the salt loss.
Various non-prescription medications can cause diarrhea as a side effect. This applies, for example, medications such as proton pump inhibitors that reduce the formation of stomach acid and taken for stomach pain and heartburn are. Known side effect is also contained in drugs for too much stomach acid, the magnesium. Anyone noticed this side effect can take up magnesium-free alternatives. Diarrhea is a side effect of cancer drugs, prescription heart medications or high doses of thyroid hormones.
"Diarrhea can also sign the overdose of a laxative to be," warns Gottwald. "Then you should reduce the dose of laxative until the stools soft but not liquid." Basically, laxatives without medical advice should not be used longer than two weeks. Exceptions are source materials from flaxseed or psyllium Indian: This laxative in high doses does not lead to diarrhea and can be taken long term.
Diarrhea can also be caused by medication.
Berlin - Diarrhea can be a side effect of various drugs. Quite often it occurs after taking antibiotics. He usually remains harmless. More than two days, he should pause, however. Then a doctor visit is appropriate.
"Diarrhea as side effects of antibiotics are usually harmless and disappear within a few days by themselves they hold more than two days, a doctor should be consulted," says Thorsten Gottwald of the Federal Chamber of Pharmacists, Berlin. Antibiotics kill bacteria and thus also some of the desirable intestinal bacteria. One possible result is diarrhea because nutrients are not completely degraded by the intestinal bacteria. Anyone who has diarrhea should drink a lot and replace the salt loss.
Various non-prescription medications can cause diarrhea as a side effect. This applies, for example, medications such as proton pump inhibitors that reduce the formation of stomach acid and taken for stomach pain and heartburn are. Known side effect is also contained in drugs for too much stomach acid, the magnesium. Anyone noticed this side effect can take up magnesium-free alternatives. Diarrhea is a side effect of cancer drugs, prescription heart medications or high doses of thyroid hormones.
"Diarrhea can also sign the overdose of a laxative to be," warns Gottwald. "Then you should reduce the dose of laxative until the stools soft but not liquid." Basically, laxatives without medical advice should not be used longer than two weeks. Exceptions are source materials from flaxseed or psyllium Indian: This laxative in high doses does not lead to diarrhea and can be taken long term.
Most accidents with blood thinners and insulin
If old people need to be hospitalized due to side effects, only a few drugs are involved. Trigger in two out of three cases, blood thinners or diabetes agents. Researchers warn that the problem could grow.
Polypharmacy exacerbates the risk of side effects.
ATLANTA (rb / ice). If old people need to be hospitalized due to side effects, only a few drugs are involved. Trigger in two out of three cases: Vitamin K antagonists, antiplatelet agents, insulins and oral antidiabetics.
Researchers at the U.S. Centers for Disease Control and Prevention have now compiled data on hospital treatments for severe adverse drug reactions of about 5000 patients aged 65 years in the USA (NEJM 2011; 365: 2002).
Half of those affected had been the 80th Age exceeded. In two thirds of cases of overdose had caused the incident.
Four drugs or drug classes were - individually or in combination - to 67 percent involved warfarin (33 percent), insulin (14 percent), oral antiplatelet drugs (13 percent) and oral hypoglycemic agents (11 percent).
Management for fewer hospital admissions
High-risk medications two spent only 1.2 percent of the events involved. These included the researchers about the antipsychotic thioridazine, the calcium channel blocker nifedipine and some long-acting benzodiazepines such as diazepam all have side effects.
Through improved management of antithrombotic and antidiabetic therapies themselves could avoid hospital admissions due to drug side effects, the researchers said.
They warn that the increasing polypharmacy in the elderly in the future will exacerbate the problem. So take 40 percent of the over-65s in the U.S. five to ten medications daily, 18 percent as much as ten or more drugs.
Polypharmacy exacerbates the risk of side effects.
ATLANTA (rb / ice). If old people need to be hospitalized due to side effects, only a few drugs are involved. Trigger in two out of three cases: Vitamin K antagonists, antiplatelet agents, insulins and oral antidiabetics.
Researchers at the U.S. Centers for Disease Control and Prevention have now compiled data on hospital treatments for severe adverse drug reactions of about 5000 patients aged 65 years in the USA (NEJM 2011; 365: 2002).
Half of those affected had been the 80th Age exceeded. In two thirds of cases of overdose had caused the incident.
Four drugs or drug classes were - individually or in combination - to 67 percent involved warfarin (33 percent), insulin (14 percent), oral antiplatelet drugs (13 percent) and oral hypoglycemic agents (11 percent).
Management for fewer hospital admissions
High-risk medications two spent only 1.2 percent of the events involved. These included the researchers about the antipsychotic thioridazine, the calcium channel blocker nifedipine and some long-acting benzodiazepines such as diazepam all have side effects.
Through improved management of antithrombotic and antidiabetic therapies themselves could avoid hospital admissions due to drug side effects, the researchers said.
They warn that the increasing polypharmacy in the elderly in the future will exacerbate the problem. So take 40 percent of the over-65s in the U.S. five to ten medications daily, 18 percent as much as ten or more drugs.
Bayer: From risks and side effects
In the U.S., what could be brewing for Bayer. For thousands of affected women want to complain against the pharmaceutical giant for alleged negative effects of birth control pills for the Group. That could be expensive.
The Leverkusen-based company is said to have the approval of its birth control pill Yasmin in 2001, the U.S. authorities do not adequately informed about possible risks and side effects. The said David Kessler, former head of the U.S. Food and Drug Administration in court dispute over the contraceptive Yasmin and Yaz. Thus, Bayer confronted with serious accusations.
It's mostly about alleged risks of thrombosis from Yasmin, which was already approved in 2001 and is also true for drug tests, had appeared in which dangerous blood clots in women. These allegations are now produced from files that were open on Monday in a court in the U.S. state of Illinois.
Bayer
47.17 +0.13 +0.28%
Wave of action
Thousands of women in the U.S. now sue for damages. Those claims is not to be trifled known. By early October, the number of applicants has already increased to 10,400. Although the company is insured against product liability risks, but it is feared that this will not suffice for a conviction. Bayer declined to comment on the matter and referred to the ongoing process: "This is is a matter which is the subject of ongoing legal proceedings and will be dealt with accordingly in court," said a spokesman. Bayer plans but decided to defend against the allegations.
Particularly important will be how the experts committee to the FDA expresses that deals with the matter this week. His vote is of great importance for the future of Bayer pills in the U.S..
One of the most important business
The threat to Bayer becomes clearer if one bears in mind that the birth control pill Yasmin product family with an annual turnover of 1.1 billion euros, the second largest group in the pharmaceutical sales business are. A further complication is that sales are declining, because the competition is located in the neck Bayer difficult. Many vendors offer generic copycat products and provide sales declines. Within a year there were at least 13.1 percent.
Bayer stock hardly responds
Investors measure the threat of litigation in the U.S. today, however, no direct meaning. Bayer shares fall in line with a market yielding 0.9 percent to 47.20 euros
The Leverkusen-based company is said to have the approval of its birth control pill Yasmin in 2001, the U.S. authorities do not adequately informed about possible risks and side effects. The said David Kessler, former head of the U.S. Food and Drug Administration in court dispute over the contraceptive Yasmin and Yaz. Thus, Bayer confronted with serious accusations.
It's mostly about alleged risks of thrombosis from Yasmin, which was already approved in 2001 and is also true for drug tests, had appeared in which dangerous blood clots in women. These allegations are now produced from files that were open on Monday in a court in the U.S. state of Illinois.
Bayer
47.17 +0.13 +0.28%
Wave of action
Thousands of women in the U.S. now sue for damages. Those claims is not to be trifled known. By early October, the number of applicants has already increased to 10,400. Although the company is insured against product liability risks, but it is feared that this will not suffice for a conviction. Bayer declined to comment on the matter and referred to the ongoing process: "This is is a matter which is the subject of ongoing legal proceedings and will be dealt with accordingly in court," said a spokesman. Bayer plans but decided to defend against the allegations.
Particularly important will be how the experts committee to the FDA expresses that deals with the matter this week. His vote is of great importance for the future of Bayer pills in the U.S..
One of the most important business
The threat to Bayer becomes clearer if one bears in mind that the birth control pill Yasmin product family with an annual turnover of 1.1 billion euros, the second largest group in the pharmaceutical sales business are. A further complication is that sales are declining, because the competition is located in the neck Bayer difficult. Many vendors offer generic copycat products and provide sales declines. Within a year there were at least 13.1 percent.
Bayer stock hardly responds
Investors measure the threat of litigation in the U.S. today, however, no direct meaning. Bayer shares fall in line with a market yielding 0.9 percent to 47.20 euros
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